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Spotlight on Vision with Anthony Castore

Seeing Clearly: Emerging Treatments for Vision Problems

Vision problems have become a common issue for many people worldwide. With the advancements in technology, more and more people have become glued to their screens, leading to an increase in eye strain and other vision problems. Over time, traditional treatments such as glasses, contact lenses, and surgical procedures have been utilized. However, in recent years, several emerging treatments have shown a promising rate of success in treating vision problems. In this article, we’ll discuss the latest emerging treatments such as RGN-259, Visomitin, A5, A7, A11 Bioregulator Peptides, Can C eye drops, Red Light Therapy, Normoftol, BPC 157 and their ability to restore vision.

RGN-259:

RGN-259, a topical eye drop, has shown promising results in treating dry eye syndrome, a condition where the eye fails to produce enough tears, leading to dryness and inflammation. Clinical studies have revealed that after just two weeks of treatment, the drop can significantly reduce dry eye symptoms and improve overall eye health.

RGN-259 is a sterile and preservative-free eye drop that contains Thymosin beta 4 (Tβ4) as its active ingredient[2]. It has been developed by RegeneRx Biopharmaceuticals for the treatment of various ocular diseases, including dry eye syndrome and neurotrophic keratopathy[2][3].

**Mechanism of Action**

RGN-259 works by promoting the healing of persistent epithelial defects in the cornea[1]. Tβ4, the active ingredient in RGN-259, has anti-inflammatory and wound-healing properties[3]. It has been shown to improve corneal integrity, reduce inflammation, and promote recovery of mucins and goblet cells in a dry eye mouse model[5].

**Applications**

RGN-259 has been studied for the treatment of dry eye syndrome and neurotrophic keratopathy[1][2][3]. In a Phase 2 clinical trial for dry eye syndrome, RGN-259 was found to improve ocular comfort and reduce corneal staining[3]. In a Phase 3 clinical trial for neurotrophic keratopathy, RGN-259 was found to be effective in promoting the healing of persistent epithelial defects in patients with Stage 2 and 3 disease[1].

**Dose Studies, Results, and Safety Profile**

A study published in December 2022 found that the use of 0.1% RGN-259 promotes rapid healing of epithelial defects in neurotrophic keratopathy, improves ocular comfort, and is well-tolerated[4]. The study included a treated group and a placebo group, and the findings showed fast and complete healing by 4 weeks in the treated group vs. placebo group[4]. There were no safety issues reported, and only minor differences were noted in the slit-lamp biomicroscopy from baseline[4]. Another study found that RGN-259 was effective in healing chronic corneal ulcers resulting from neurotrophic keratopathy in six patients[6].

Overall, RGN-259 appears to be a promising treatment option for various ocular diseases. It has a novel mechanism of action and has shown positive results in clinical trials. Further studies are needed to fully evaluate its efficacy and safety.

Sources

[1] Publication of RGN-259 Phase 3 Clinical Trial Results in Patients with Neurotrophic Keratopathy – PR Newswire https://www.prnewswire.com/news-releases/publication-of-rgn-259-phase-3-clinical-trial-results-in-patients-with-neurotrophic-keratopathy-301712318.html

[2] RGN-259 – RegeneRx http://www.regenerx.com/RGN-259

[3] RegeneRx Reports Positive Data with RGN-259 in Phase 2 Dry Eye Trial – Ora Clinical https://www.oraclinical.com/resource/regenerx-reports-positive-data-with-rgn-259-in-phase-2-dry-eye-trial/

[4] 0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820614/

[5] RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043477/

[6] RegeneRx Allowed to Proceed with Phase 3 Using RGN-259 Eye Drops for the Treatment of Neurotrophic Keratopathy | Fierce Biotech https://www.fiercebiotech.com/biotech/regenerx-allowed-to-proceed-phase-3-using-rgn-259-eye-drops-for-treatment-of-neurotrophic

Visomitin:

Visomitin, a revolutionary eye drop, has been making waves in the medical industry with its ability to restore vision by promoting the regeneration of damaged eye cells. Clinical trials have shown that Visomitin works effectively in the treatment of cataracts, glaucoma, macular degeneration, and other vision problems. The drug has been found to be very safe, with no harmful side effects.

Visomitin is an eye drop formulation that contains SkQ1, a mitochondria-targeted antioxidant, as its active ingredient[2][6]. It is under development for multiple indications, including dry eye disease (DED), glaucoma, and Leber’s hereditary optic neuropathy (LHON) [3][4].

**Mechanism of Action**

Visomitin’s mechanism of action addresses the most important clinical needs in dry eye disease, including tear quality, cornea/conjunctiva healing rate, and inflammation[2]. SkQ1, the active ingredient in Visomitin, is a potent antioxidant that can protect the mitochondria from oxidative stress and improve the function of the respiratory chain[6]. SkQ1 has been shown to reduce inflammation and promote wound healing in the ocular surface[6].

**Applications**

Visomitin has been studied for the treatment of dry eye syndrome[1][5]. A multicenter, randomized, double-masked, placebo-controlled clinical study found that Visomitin is effective and safe for use in eye patients with dry eye syndrome for protection from corneal damage[1]. Visomitin has also been studied for the treatment of glaucoma and LHON[3][4].

**Dose Studies, Results, and Safety Profile**

A Phase II clinical trial of Visomitin in dry eye patients utilizing the controlled adverse environment found that Visomitin was well-tolerated and showed a significant improvement in the corneal and conjunctival staining scores compared to the placebo group[5]. Another study found that Visomitin was effective in reducing inflammation and promoting wound healing of the ocular surface[6].

Overall, Visomitin appears to be a promising treatment option for various ocular diseases. It has a novel mechanism of action and has shown positive results in clinical trials. Further studies are needed to fully evaluate its efficacy and safety.

Sources

[1] Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome – PMC – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679790/

[2] Clinical Programs – Mitotech https://www.mitotechpharma.com/programs/

[3] Mitotech to Host Key Opinion Leader Webinar on Visomitin®: A Potential Treatment for Dry Eye Disease https://www.mitotechpharma.com/news/mitotech-to-host-key-opinion-leader-webinar-on-visomitin-a-potential-treatment-for-dry-eye-disease/

[4] Mitotech CSO to present at Mitochondria-Targeted Drug Development Summit https://www.mitotechpharma.com/news/mitotech-cso-to-present-visomitin-data-in-dry-eye-disease-and-glaucoma/

[5] Mitotech S.A. announces the initiation of Phase II clinical trial in Dry Eye Patients Utilizing the Controlled Adverse Environment https://www.mitotechpharma.com/news/mitotech-s.a.-announces-the-initiation-of-phase-ii-clinical-trial-in-dry-eye-patients-utilizing-the-controlled-adverse-environment/

[6] The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface – PMC – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393248/

Bioregulator peptides, such as A5, A7, and A11, have profound therapeutic effects in treating age-related vision and other eye problems. A study conducted on aging retinal pigment epithelial cells (RPE) showed that treatment with A5, A7, and A11 peptides activated several cellular pathways that are essential for the healing of the damaged eye tissues.

Bioregulator peptides A5, A7, and A11 are short chains of amino acids that have been studied for their potential role in eye health. Here is a breakdown of each peptide:

A5

– Role in Eye Health: A5 has been studied for its potential to improve visual acuity and reduce the risk of age-related macular degeneration (AMD)[1].

– Mechanism of Action: A5 is believed to work by activating genes that promote cellular regeneration and protein synthesis[1].

– Dose Studied: The specific dose of A5 studied for eye health is unclear from the search results.

– Results: A study published in 2019 found that A5 improved visual acuity in patients with early-stage AMD[1]. However, further studies are needed to confirm these findings.

– Safety Profile: The safety profile of A5 is unclear from the search results.

A7

– Role in Eye Health: A7 has been studied for its potential to improve visual acuity and reduce the risk of AMD[1].

– Mechanism of Action: A7 is believed to work by activating genes that promote cellular regeneration and protein synthesis[1].

– Dose Studied: The specific dose of A7 studied for eye health is unclear from the search results.

– Results: A study published in 2019 found that A7 improved visual acuity in patients with early-stage AMD[1]. However, further studies are needed to confirm these findings.

– Safety Profile: The safety profile of A7 is unclear from the search results.

A11

– Role in Eye Health: A11 has been studied for its potential to improve visual acuity and reduce the risk of AMD[1].

– Mechanism of Action: A11 is believed to work by activating genes that promote cellular regeneration and protein synthesis[1].

– Dose Studied: The specific dose of A11 studied for eye health is unclear from the search results.

– Results: A study published in 2019 found that A11 improved visual acuity in patients with early-stage AMD[1]. However, further studies are needed to confirm these findings.

– Safety Profile: The safety profile of A11 is unclear from the search results.

Overall, while these peptides show promise in improving visual acuity and reducing the risk of AMD, further studies are needed to determine their optimal dosage and safety profile. It is important to consult with a healthcare provider before using any peptide bioregulators for eye health.

Sources

[1] What Are Peptide Bioregulators and How Do They Work? https://yuniquemedical.com/peptide-bioregulators/

[2] What Are Peptides and What Are They Used For? – Health https://www.health.com/what-are-peptides-7106093

[3] Episode #96: What’s New In Peptide Bioregulator Research, Protocols, and Supplements https://youtube.com/watch?v=koDLR44k7uI

[4] The Body’s Own Bioweapons – Jonathan B. Tucker, 2008 https://journals.sagepub.com/doi/full/10.2968/064001006

[5] The New Darlings Of The Anti-Aging Industry & Secret Age Reversal Weapon: Peptide Bioregulators – YouTube https://youtube.com/watch?v=-zXci5vZ7rY

[6] Peptides for Brain, Neuropathy, BioRegulators – Livagen, Pancreagen, Cardiogen, Pinealon & Cortagen – YouTube https://youtube.com/watch?v=ii0tcyMyrlk

Can-C Eye Drops:

Can-C eye drops contain a unique active ingredient, N-Acetyl-Carnosine, which has been shown to effectively treat cataracts. Clinical studies have proved that Can-C eye drops can reduce cataract forms gradually while preserving the remaining lens cells’ transparency. The eye drops have proved to be safe for all ages, including pregnant women.

Can-C Eye Drops are a lubricant eye drop formulation that contains N-acetylcarnosine (NAC) as its active ingredient[1][2]. It is marketed as an anti-aging breakthrough and is used to treat a range of ophthalmic disorders, including cataracts, dry eye, and glaucoma[2][4].

**Mechanism of Action**

Can-C Eye Drops work by delivering NAC to the eye, which is believed to have antioxidant properties and can help reduce oxidative stress in the eye[1][5]. NAC is a prodrug of L-carnosine, which is a natural antioxidant that can help protect the eye from damage caused by free radicals[1].

**Dose Studied, Results, and Safety Profile**

The specific dose of Can-C Eye Drops studied for eye health is unclear from the search results. However, a study published in 2009 found that NAC eye drops improved glare sensitivity, cataract amelioration, and quality of vision in patients with age-related vision problems[1]. Another study published in 2014 found that Can-C Eye Drops were effective in treating cataracts and dry eyes[3].

Can-C Eye Drops are generally considered safe and well-tolerated, with no reported side effects or contraindications[2]. However, it is important to consult with a healthcare provider before using Can-C Eye Drops or any other medication for the treatment of eye disorders.

Overall, Can-C Eye Drops appear to be a promising treatment option for various ophthalmic disorders. It has a novel mechanism of action and has shown positive results in clinical trials. However, further studies are needed to determine the optimal dosage and long-term safety profile of Can-C Eye Drops.

Sources

[1] N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685223/

[2] Can-C | Side Effects- What You Need To Know Before Buying – Eye Lounge https://www.eyelounge.co.uk/pages/can-c-side-effects-what-you-need-to-know-before-buying

[3] Amazon.com: Can-C Lubricant Eye Drops with Antioxidant N-Acetylcarnosine | Effective Solution for Cataracts & Dry Eyes https://www.amazon.com/Lubricant-Antioxidant-N-Acetylcarnosine-Effective-Peermax/dp/B08M48BQYF

[4] n-acetylcarnosine lubricant eye: Topics by Science.gov https://www.science.gov/topicpages/n/n-acetylcarnosine+lubricant+eye

[5] (PDF) N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision – ResearchGate https://www.researchgate.net/publication/26273653_N-Acetylcarnosine_sustained_drug_delivery_eye_drops_to_control_the_signs_of_ageless_vision_Glare_sensitivity_cataract_amelioration_and_quality_of_vision_currently_available_treatment_for_the_challengi

[6] Restasis (cyclosporine): Side effects, dosage, and more – Medical News Today https://www.medicalnewstoday.com/articles/restasis

Normoftol:

Normoftol is a natural treatment for vision problems. It is an olive oil-derived product that works by nourishing the eye tissues from within, promoting faster healing, and enhancing overall eye health. Normoftol has been found to treat various eye problems such as dry eyes, blurry vision, and even night vision issues.

**Normoftal (Lys-Glu)**

Normoftal (Lys-Glu) is a peptide that has been studied for its potential to improve eye health, particularly in the treatment of vitreous floaters[1].

**Role in Eye Health**

Normoftal (Lys-Glu) has been studied for its potential to improve vitreous health and reduce the appearance of floaters in the eye[1].

**Mechanism of Action**

The mechanism of action of Normoftal (Lys-Glu) is unclear from the search results.

**Doses Studied and Results**

The specific doses of Normoftal (Lys-Glu) studied for eye health are unclear from the search results. However, a supplement called VitreousHealth, which contains Normoftal (Lys-Glu) as one of its active ingredients, has been shown to improve vitreous health and reduce the appearance of floaters in the eye[1].

**Safety Profile**

The safety profile of Normoftal (Lys-Glu) is unclear from the search results. However, VitreousHealth, which contains Normoftal (Lys-Glu), is marketed as a scientifically proven supplement for eye floaters and is generally considered safe and well-tolerated[1].

Overall, Normoftal (Lys-Glu) appears to be a promising treatment option for vitreous floaters. However, further studies are needed to determine its optimal dosage and long-term safety profile. It is important to consult with a healthcare provider before using Normoftal (Lys-Glu) or any other supplement for the treatment of eye disorders.

Sources

[1] VitreousHealth Is The 1st Scientifically Proven Supplement For Eye Floaters – YouTube https://youtube.com/watch?v=Yx_qJ9v7dY4

[2] RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043477/

[3] (PDF) N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision – ResearchGate https://www.researchgate.net/publication/26273653_N-Acetylcarnosine_sustained_drug_delivery_eye_drops_to_control_the_signs_of_ageless_vision_Glare_sensitivity_cataract_amelioration_and_quality_of_vision_currently_available_treatment_for_the_challengi

[4] Mitotech S.A. announces the initiation of Phase II clinical trial in Dry Eye Patients Utilizing the Controlled Adverse Environment https://www.mitotechpharma.com/news/mitotech-s.a.-announces-the-initiation-of-phase-ii-clinical-trial-in-dry-eye-patients-utilizing-the-controlled-adverse-environment/

[5] N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685223/

[6] n-acetylcarnosine lubricant eye: Topics by Science.gov https://www.science.gov/topicpages/n/n-acetylcarnosine+lubricant+eye

BPC 157:

BPC 157 is a peptide that has shown immense success in treating injured tissues. BPC 157 acts by activating various repair mechanisms and promoting faster healing of damaged eye tissues. The drug has been found to treat various vision problems such as cataracts, macular degeneration, and even glaucoma.

**BPC 157**

BPC 157 is a synthetic peptide that has been studied for its potential to improve eye health. Here is a breakdown of the available information:

**Role in Eye Health**

BPC 157 has been studied for its potential to improve eye health in various ways, including:

– Treating glaucoma[2]

– Improving vitreous health and reducing the appearance of floaters[1]

– Treating corneal injuries[4]

**Mechanism of Action**

The mechanism of action of BPC 157 is unclear from the search results. However, it is believed to have anti-inflammatory and wound-healing properties[2].

**Doses Studied and Administration**

The specific doses of BPC 157 studied for eye health vary depending on the study. BPC 157 has been administered locally as eye drops, intraperitoneally, and subcutaneously[2].

**Results**

Studies have shown that BPC 157 has potential benefits for eye health, including:

– Improving vitreous health and reducing the appearance of floaters[1]

– Treating glaucoma[2]

– Treating corneal injuries[4]

– Counteracting atropine-mydriasis[5]

However, it is important to note that a Reddit post warns against using BPC-157 eye drops, as it can induce angiogenesis, which can cause retinal bleeding and lead to permanent blindness[1].

**Safety Profile**

The safety profile of BPC 157 is unclear from the search results. However, it is important to note that a Reddit post warns against using BPC-157 eye drops, as it can induce angiogenesis, which can cause retinal bleeding and lead to permanent blindness[1].

Overall, while BPC 157 shows promise in improving eye health, further studies are needed to determine its optimal dosage and long-term safety profile. It is important to consult with a healthcare provider before using BPC 157 or any other supplement for the treatment of eye disorders.

Sources

[1] Do NOT use BPC-157 eye drops, you might go blind permanently: It induces angiogenesis, which can cause retinal bleeding – Reddit https://www.reddit.com/r/Nootropics/comments/9whhnq/do_not_use_bpc157_eye_drops_you_might_go_blind/

[2] Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma – PMC – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773185/

[3] Characteristic eye presentation in BPC 157 treated eye 32 hours after… – ResearchGate https://www.researchgate.net/figure/Characteristic-eye-presentation-in-BPC-157-treated-eye-32-hours-after-the-entire_fig4_7644110

[4] Perforating corneal injury in rat and pentadecapeptide BPC 157 – ScienceDirect.com https://www.sciencedirect.com/science/article/abs/pii/S0014483515001360

[5] BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats – Frontiers https://www.frontiersin.org/articles/10.3389/fphar.2021.632295/full

[6] BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats – PMC – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222724/

Red Light Therapy for Improving Vision

Red Light Therapy (RLT) has been found to be an effective treatment for age-related vision problems. Red light therapy works by stimulating cellular metabolism, thus promoting the regeneration of damaged retina cells. The red light wavelengths help to repair the damaged tissues and enhance the overall eye health.

Red light therapy is an emerging area of research dedicated to eye health and vision restoration. It involves the use of red light to improve mitochondrial function in retinal photoreceptor cells, which can help improve vision and treat various eye conditions[1][2][3][4][5][6]. Here is a breakdown of the available information:

**Mechanism of Action**

The mechanism of action of red light therapy is believed to involve the activation of mitochondrial function in retinal photoreceptor cells, which can help improve vision and treat various eye conditions[1][2][3][4][5][6].

**Strength of Red Light and Duration of Study**

The strength of red light and duration of study vary depending on the study. For example, a 2021 study investigated using red light to improve color vision in aged individuals and found that a single three-minute red light treatment at approximately 670 nm improved color contrast[2]. Another study found that treatment with 670 nm red light decreased retinal inflammation and improved retinal healing[4].

**Timing of Administration**

The timing of administration of red light therapy also varies depending on the study. For example, a 2021 study investigated using red light to improve color vision in aged individuals and found that a single three-minute red light treatment improved color contrast[2]. Another study found that treatment with 670 nm red light decreased retinal inflammation and improved retinal healing[4].

**Outcomes**

Studies have shown that red light therapy has potential benefits for eye health, including:

– Improving color vision in aged individuals[2]

– Treating glaucoma[3]

– Improving vitreous health and reducing the appearance of floaters[1]

– Treating corneal injuries[4]

– Reducing inflammation and protecting retinal cells from damage[6]

**Safety Profile**

Red light therapy is generally considered safe and well-tolerated, with no reported side effects or contraindications[1][2][3][4][5][6]. However, it is important to consult with a healthcare provider before using red light therapy or any other treatment for the treatment of eye disorders.

Overall, red light therapy appears to be a promising treatment option for various eye conditions. However, further studies are needed to determine its optimal dosage and long-term safety profile. It is important to consult with a healthcare provider before using red light therapy or any other treatment for the treatment of eye disorders.

Sources

[1] Can Red Light Therapy Improve Your Vision and Eye Health? – Rouge Care https://rougecare.co.uk/blogs/rouge-red-light-therapy-blog/can-red-light-therapy-improve-your-vision-and-eye-health

[2] Eye Health and Using Red Light Therapy to Improve Vision – Joovv https://joovv.com/blogs/joovv-blog/red-light-therapy-improves-vision

[3] Red light therapy could improve eyesight that has declined due to age – New Scientist https://www.newscientist.com/article/2298723-red-light-therapy-could-improve-eyesight-that-has-declined-due-to-age/

[4] Near Infrared (NIR) Light Therapy of Eye Diseases: A Review – PMC – NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738953/

[5] Red Light Therapy for Eye Health – Spero Wellness Clinic https://www.sperowellness.com/red-light-therapy-for-eye-health

[6] Is Red Led Light Therapy Bad for Your Eyes? Let’s Find Out https://platinumtherapylights.com/blogs/news/red-light-therapy-eyes

Gene Editing

One final therapy on the horizon is gene editing. I just learned of it a little over a year ago in an interview with Dr. David Sinclair. In a nutshell, in China have used a new form of CRISPR-based genome editing to restore the vision of mice with retinitis pigmentosa, an inherited condition that leads to blindness[1][2]. The team used a newly developed CRISPR-based gene-editing technique to restore the sight of mice with retinitis pigmentosa. The disease can be caused by mutations in more than 100 different genes, causing photoreceptive cells in the retina to break down slowly over time, leading to vision loss and ultimately to blindness. The researchers used the CRISPR system of gene editing, allowing them to correct gene mutations. The changes in the genome restored the enzyme’s activity in the retinas of mice and prevented the death of photoreceptors to restore normal electrical responses to light. After correcting the gene mutation, the researchers performed several behavioral tests to confirm that the mice continued their improved vision into old age. One such test was to have the mice find their way out of a visually guided water maze. The scientists found that the mice treated with the CRISPR-based technique retained their vision well into old age[2][4]. The safety profile of this gene editing therapy is unclear from the search results. There are no human trials starting up yet.

Sources

[1] Study: New gene-editing technique reverses vision loss in mice – Ophthalmology Times https://www.ophthalmologytimes.com/view/study-new-gene-editing-technique-reverses-vision-loss-in-mice

[2] Vision restored in mice using revolutionary gene-editing technique – BBC Science Focus https://www.sciencefocus.com/news/vision-restored-mice-gene-editing/

[3] Gene-editing reverses vision loss in mice – The Science Advisory Board https://www.scienceboard.net/index.aspx?itemID=5313&sec=log

[4] How CRISPR Gene Editing May Help Reverse Vision Loss – Healthline https://www.healthline.com/health-news/how-crispr-gene-editing-may-help-reverse-vision-loss

[5] Gene therapy with novel protein restores vision in mice | National Institutes of Health (NIH) https://www.nih.gov/news-events/nih-research-matters/gene-therapy-novel-protein-restores-vision-mice

[6] Blind Mice Regain Eyesight After Crispr Gene Editing – Forbes https://www.forbes.com/sites/roberthart/2023/03/17/blind-mice-regain-eyesight-after-crispr-gene-editing/?sh=24a31c841947

Emerging treatments such as RGN-259, Visomitin, A5, A7, A11 Bioregulator Peptides, Can C eye drops, Red Light Therapy, Normoftol, and BPC 157 have been found to be highly effective in treating various vision problems. Many of these treatments are safe, natural, and non-invasive, making them an excellent alternative to traditional treatments such as glasses, contacts, and surgery. If you experience any vision problems, it is always advisable to visit an optometrist or ophthalmologist for a diagnosis and treatment plan customized for your unique needs.

How Long Does It Take For PPS To Work?

Pentosan Polysulfate Sodium (PPS) is an FDA-approved drug in the United States under the brand name ELMIRON. ELMIRON is an oral medication indicated for treating bladder pain and discomfort associated with interstitial cystitis.

As usual, the Boulder Longevity Institute gets ahead of the crowd by finding a way PPS can be used in the U.S. as a beneficial regenerative medication. While not effective orally outside of its use as a bladder pain relief drug, PPS can be beneficial in the treatment of arthritis when administered via injection.

BLI partners with a compounding pharmacy to get PPS to patients now. The drug, in phase III trials approved by the FDA, will go to market in the coming years as Zilosul. 

As we know, arthritis is an inflammatory process at its core. Sure, the inflammation can be instigated by injury but we can say with confidence that addressing the inappropriate inflammatory response as quickly as possible leads to markedly better outcomes.

PPS works to address the entire inflammatory process in ways that typical treatments for arthritis pain – anti-inflammatories, steroids, joint replacements – do not. Pentosan works through various mechanisms like pain control, halting the progression of degeneration, and encouraging an environment for regeneration. 

Once a better environment for regeneration has been completed, stem cells or platelet cells can be introduced into a space where they can thrive. 

So how long does it take to work? Well, Dr. Yurth of Boulder Longevity Institute believes it depends on the extent of arthritis. Studies show pain control in 6-8 weeks with one to two injections per week. However, this is not the case for every user.

The more damage, or the further along the arthritic process, the longer PPS takes to fully engage in the work of improvement. With that said, there are those who see quick pain relief that is typically experiencing the impact PPS has on the inflammatory process.

While a relatively new use for pentosan, BLI has been using it long enough to note that 80 – 90 percent of clients see improvement over time. Patience is key, as it can take six months or so to really see regenerative impacts in the more damaged knee. 

Dr. Yurth has seen the value of pentosan firsthand, as she has been taking it for years and notes marked improvement in her chronic knee issues. Whether for chronic arthritic knees or an acute injury, pentosan is a game changer in the fight against damage brought by inflammation.

Depending on your clinical presentation, you may have to be patient. However, in the end, the benefits of pentosan polysulfate sodium are well worth the wait.

The Importance of Supplement Cycling

Most of us have understood the importance of taking a daily vitamin since childhood. Any Flintstone kids still growing out there? Taking some basic supplements on a daily, long-term basis makes sense. 

Dr. Elizabeth Yurth of the Boulder Longevity Institute points out that Vitamin D, B-Complex vitamins, or general multivitamins are logical additions to your daily supplement routine. What about the more aggressive supplements like spermidine, NAD, or antioxidants?

Using a process of supplement cycling (time on – time off specific vitamins and supplements) can help the body reap the benefits without doing unintentional damage. Certain supplements can be overwhelming when taken regularly over long time periods. 

The overwhelm can be physical, including burdening the liver as it works to filter the body of unwanted chemicals. There can be a financial toll associated with overconsuming supplements, as most of them would not be considered inexpensive. Finally, trying to keep up with supplement dosages, timing, and ingredient interactions can be downright stressful.

Human bodies are indescribably complex. The interaction of pathways, messengers, and metabolism can all be impacted by supplements. A short period of intake of certain supplements may not overwhelm these systems but over time could have negative impacts. 

Dr. Yurth offers a couple of examples, of the hundreds she can think of, describing how supplements could have unintended consequences. She notes that many supplements are tested over short periods of time, leaving us in the dark of how they impact our bodies with extended intake. 

We constantly hear about how oxidative stress is overwhelming our bodies. Social media has convinced us that throwing antioxidants at the supposed problem will tamp down the oxidative stress, and be beneficial in the long term. While many of us are inundated with this stress occurring in the body, the thought process that antioxidants are a cure all is problematic.

The problem with this approach is that not all oxidative stress is a bad thing. This stress can encourage mitochondria to respond appropriately, improving damaged cells on their own. This is a prime example of how the complicated systems in our bodies can be thrown off balance by what we think is best. Balance (homeostasis) is key.

5-HTP is another example of how less might be more. We know 5-HTP is a good supplement that positively impacts sleep, encourages true rest, and reduces stress through the increase in serotonin and melatonin it induces. What happens if we intake 5-HTP for extended periods?

Tryptophan finds another route and drives down the kynurenine pathway. This throws the appropriate system out of balance, possibly leading to neurological damage, depression, and a reduction in sleep. This is the opposite outcome we would be hoping for and is instigated by too much 5-HTP.

The loss of vital homeostasis is a real threat when taking certain supplements for long durations. This is how cycling helps. Taking breaks via these cycles allows the balance to remain in place. Your liver gets a break and the body is allowed to reset. 

Dr. Yurth also points out how the body typically reacts to inputs like supplements or exercise. It adapts. Doing the same thing over and over leads to a plateau in results. Cycling supplements or changing exercise routines challenges the body to keep improving.

The assistance of someone like the specialists at Boulder Longevity Institute is certainly helpful. We have seen how challenging it can be to know what to take, how long, and how much. Getting the perspective of a professional is the best bet for those taking supplements other than the typical everyday vitamins. 

For those seeking a DIY approach, take your basic supplements regularly. For more aggressive supplements, consider 12 weeks on and 12 weeks off cycles to allow your body to rest, recuperate, and react appropriately.

The body needs homeostasis. Cycling supplements can protect the cells and maintain balance over time. Balance is key.

Peptides: The Next Step to Health Optimization

Peptides, The Next Step in Human Optimization

Peptides are short chains of amino acids found throughout our bodies in virtually every cell. They are responsible for signaling and communication in the body, aiding in nearly every core biological system from brain function to fat storage. They can also help with insulin control, manage sleep disorders, and promote overall longevity. However, much like our hormone levels decline with age, our naturally occurring peptides and amino acids decrease as we age. This decrease can lead to increased fat and muscle loss starting as early as your mid 20s or early 30s. Peptide therapy, similar to hormone therapy, can provide our bodies with those essential amino acids once again and kickstart the regeneration process.

There is such a wide range of peptides and functions, from wound healing to glucose management. Some of the more popular and well known peptides include BPC-157, thymic peptides, and GLP-1 agonists.  

BPC-157 can aid in healing and regeneration throughout the body, including wounds and tissue rejuvenation. It can be taken orally or through an injection. When taken orally, BPC-157 can aid in gut tissue and ulcer treatment, along with ulcerative colitis. When taken as an injection, BPC-157 is best for musculoskeletal injuries. This is achieved through the production of nitrous oxide and other crucial growth factors, which assist in making new blood vessels. It promotes the physiological processes that take place in the event of wound healing and tissue regeneration.

Similarly, thymic peptides encourage normal immune function and healing. Such peptides originate from our thymus gland, a small organ found near our upper chest. In our thymus gland, immune T cells are generated and trained to fight off infections and cancerous cells. However, the size of our thymus shrinks as we age, and as a result our naturally occurring thymic peptides decrease, leading to a decrease in overall immune function. Subsequently, supplying our bodies with thymic peptides aids in immune system health and healing. Common thymic peptides include Thymosin Alpha-1, Thymulin and Thymosin Beta-4. Thymosin Beta4 is often paired with BPC for collagen growth and healing as well.

GLP-1 agonists such as semaglutide are similar to those that our body makes. Although compounded and chemically synthesized, GLP-1 agonists like semaglutide act like the peptide that our bodies naturally make. While GLP-1 agonists were originally taken for glucose management, they are now administered for additional lifestyle maintenance and management purposes. For example, they can help with appetite control, body weight, blood pressure, plasma glucose, and plasma lipids. While these agonists are generally well tolerated, there may be some nausea early on as the body adjusts to the chemically synthesized peptides.

While all of these peptides are beneficial in theory, not all peptides are equal. Buying from a reputable source is important to your health and longevity. “Research-only” peptides you can buy off the internet are often compounded with fillers and lack sterility and purity testing. Getting your peptides prescribed by a a physician that sources their peptides from a FDA-approved compounding pharmacy ensures safety and efficacy.  Peptides need to be taken in the right order, amounts, and proportions, so working with certified professionals and physicians is recommended. Navigating peptides alone is like touring a museum without a tour guide, you are unlikely to get much out of it…and you might even stumble into an area marked off limits



Reasons to NOT Worry if You Run Out of Your Prescription

There can be an overwhelming dread when you realize you have run out of your prescription unexpectedly. Whether it be a hormone, peptides, or drugs like pentosan polysulfate sodium, you likely do not need to be worried. 

The majority of hormones, peptides, and drug treatments offer a build up effect in our system. This allows their impact to remain even without taking the prescription for a short time.

Additionally, the ideal benefit of these treatments is some semblance of a systemic improvement. Thus, the improved cellular function can tolerate short durations of change.

Ideally, keep an eye on your supplies. If a weekend or vacation is approaching, take stock of how much you have remaining and what you might need. 

In the event you do run out, remain calm. Your body will handle the downtime by using built-up impacts, improved cellular function, and may even benefit from a short break from treatments. Have your prescription refilled or addressed as soon as possible and rest easy knowing you will be okay.

Is this the year we finally take a new approach to treating joint & back pain?

WE NEED TO FUNDAMENTALLY SHIFT THE WAY WE THINK ABOUT TREATING JOINT & BACK PAIN.

In this recorded live lecture, Dr. Yurth shares the latest science and research on what’s causing your joint & back pain and how to treat it – not simply patch, replace, or fuse it. In this intimate hour-long session, you’ll learn why our traditional approach to joint & back pain is largely stuck in the Dark Ages, how to think about arthritis as a disease that we must address at the cellular level, and what science-backed methods are available to treat, and even reverse, your pain.


DID YOU KNOW…

  • The technology used for hip and knee replacements looks virtually identical to that used 30 years ago.
  • Scoping a knee has become a largely obsolete practice in Europe due to its minimal, and sometimes harmful, effect in treatment of osteoarthritic knee pain.
  • Just like your brain doesn’t wear out from thinking too hard, your joints don’t wear out from continued use – arthritis is a degenerative disease state!

With her combined expertise in orthopedics and functional medicine, Dr. Yurth will share regenerative and cellular treatment options aimed at helping to address the root cause of your pain and how to not only alleviate issues, but actually regenerate and heal.

Play Video

TREATING JOINT AND BACK PAIN

As technologies continue to change and evolve, the treatment of joint replacement and osteoarthritis has remained stagnant. Osteoarthritis, a joint degradation that leads to cartilage death and thickening of the joint lining, is the third leading cause of disabling pain as we get older.

Arthritis is a disease that progresses with age. It is not stationary to one area. Instead, a complete cellular process takes place that affects our entire system, not just the painful joint.

Traditional treatments for joint pain have included injections such as steroids and hyaluronic acid that are injected into the site of pain. However, these tend to provide short-term relief. An article in 2019 found that steroids worsened disease progression. As for hyaluronic acid, 28% of patients had surgery within 7 months of receiving the injection.  

Surgery has been another method, as knee replacement surgery is one of the leading procedures done in the United States. A British medical journal analyzed all of the available orthopedic medical surgeries, including knee replacement, and found only one to be viable and useful, which was carpal tunnel release. A similar type of surgery, known as arthroscopic surgery, goes in and “cleans up” the area around the joint. However, it has been banned in other countries outside the US after being found to worsen conditions instead of healing. Though there is a time and place for surgery, it should be analyzed on a personal basis that takes into account the drawbacks and data – and not the initial “go-to” solution.

While traditional methods focus on a target area of the body, next generation regenerative medicine focuses on healing the cellular processes that lead to pain throughout the body. Within our bodies, inflammaging, mitochondrial dysfunction, and damaged senescent cells can all lead to pain. When in balance, all of these processes play a critical role in healing and supporting our immune system. For example, mitochondria produce ATP to aid in the healing process and autophagy helps to reduce the impact of damaged, senescent cells (think of taking out the trash). However, when our immune system is not in balance, mitochondria may accumulate too many reactive oxygen species, which lead to too many damaged proteins for autophagy to get rid of, leading to pain. Next generation treatments to help these processes include pharmaceuticals, hormone support, and peptide therapies.

Pharmaceuticals and hormonal support have a wide range of uses and types. One type of pharmaceutical includes repurposed drugs. This includes medications that are FDA approved for certain purposes but can aid in the healing of other conditions as well. For example, a compelling option includes PPS, or Pentosan Polysulfate, which is currently being used in other countries as a common treatment for osteoarthritis to reduce inflammatory cytokines and improve cartilage functions.

Peptide therapies also serve as an option to target cellular processes. Peptides are good for repair because they have specific coding for specific actions, including promoting longevity. One example of a peptide includes BPC-157, which is found in our gut, that promotes healing. AOD-9604, another type of peptide, paired with supplements such as hyaluronic acid (HA), can help complete cartilage regeneration.

Overall, arthritis is a disease that is not stationary to one part of the body, nor is it an inevitable result of “wear-and-tear” as we age. Instead, there is a complete cellular process taking place affecting our entire body, not just the joint. It is for this reason that next generation regeneration therapy such as pharmaceuticals and peptides should be considered as treatments to rebalance these cellular processes and reduce joint and osteoarthritis pain.

Want to learn more?

Check out our QuickCourse - Treating Joint & Pack Bain: Beyond the Dark Ages
Learn More

Unraveling the Myths of Hormone Replacement Therapy and Cancer

Unraveling the Myths of Hormone Replacement Therapy and Cancer

There is a good chance you have heard that hormone replacement therapy (HRT) or hormone therapy (HT) causes cancer. If you have a family medical history that includes cancer, you have almost certainly been told by a physician that HRT carries a high risk.

Unfortunately, this is a wildly dangerous myth being propagated by countless physicians based on a study from 2002, called the Women’s Health Initiative (WHI). What you should know right away is the study has been largely disproven. 

 

Unraveling the Information Regarding Hormone Replacement & Cancer Risk

When discussing hormone replacement therapy, it is not uncommon to hear someone voice the concern, “But don’t hormones cause cancer?”Unfortunately, despite multiple studies over many decades refuting this claim, this belief persists – in large part as a result of a single study published in 2002 called the Women’s Health Initiative. The published article suggested that post-menopausal women taking a combination of estrogen and progestin were at an increased risk for heart disease, stroke, cancer, and blood clots. However, what is often overlooked is this study’s finding that also showed that those taking estrogen alone showed no increased risk. Taken together, the study indicated that it was the progestin, a synthetic form of progesterone (as opposed to the natural hormone progesterone), which led to increased risks – not the estrogen.

The 2002 study became widespread, and with it, concerns about hormone replacement therapy (HRT). Over the following years, there was a drastic drop in HRT usage as a result of the WHI. In 1999-2000, the total use rate of HRT in the United States was 38.3%, and in 2003, Norway and Sweden saw a 70% drop in HRT use. 

After the widespread discontinuation of hormone therapy, some interesting trends emerged. The decrease in hormone replacement yielded opposite outcomes than originally expected. 2004 to 2005 saw an increase in age-adjusted osteoporosis, a condition well-documented as linked to age-related decline in hormones. . Additionally, breast cancer rates remained unchanged.

After observing the opposite outcomes of stopping hormone therapy, doctors and physicians decided to analyze more data and re-evaluate the 2002 study. Further investigation of the original study yielded inconsistencies and potential biases. Of those in the original 2002 study, 50% were smokers, 50% were fat or obese, and for some women 10-20 years into menopause, the damages had already occurred. Overall, the majority of the original subjects had increased symptomatology due to their current lifestyles, not due to hormone replacement therapy.

Evidence refuting the 2002 article was also compiled. A 2003 update to the 2002 study showed no such hormone-induced increase in breast cancer. Additionally, evidence of the delivery of the hormones was shown to affect risks. Oral estrogen, such as found in birth control, shows an increased risk of blood clots and venous thrombosis, with no change in mortality. However, oral estrogen is filtered through the liver, which causes the increased risk. Transdermal estrogen, the type used in bioidentical hormone therapy, bypasses the liver and therefore eliminates the risk associated with oral estrogen. Evidence suggests it may even reduce the risk of blood clots and venous thrombosis. Similarly, bioidentical progesterone, unlike the synthetic progestin, has been well researched and documented for its many health benefits from sleep to weight management and more. 

Sadly, even today, many physicians as well as the United States Preventive Services Task Force (USPSTF) advise against such therapies based on the original 2002 results. Overall, bioidentical hormone replacement therapy is a sex-specific therapy meant to aid in the reduction of breast cancer, bone fractures, cancer mortality, and more. While a single early 2002 study suggested an increased cancer and blood-clot risk, dozens more recent studies have refuted such claims. Hormone therapies are available as an aid to women and men in maintaining their physiological health without increased risks – and arguably are critical to healthy aging and overcoming the traditional decline associated with reduced hormone levels as we age.

 

Want to learn more?

Check out our QuickCourse - What to Fix First - to learn how hormones play a foundational role in our health.
Learn More

Trigger Autophagy Without Fasting – Dr. Elizabeth Yurth Talks Spermidine with Dave Asprey

Dr. Yurth is thrilled to be a guest on Bulletproof Radio with Dave Asprey.  Dave Asprey is a three-time New York Times bestselling science author, host of the Webby award-winning podcast Bulletproof Radio, and has been featured on the Today Show, CNN, The New York Times, Dr. Oz, and more.  

Follow along as Dave Asprey hosts Dr. Yurth on his 773rd episode of Bulletproof Radio, discussing the latest ways to upgrade your mind, body, and life.
“In this episode of Bulletproof Radio, my guest Dr. Elizabeth Yurth explains how spermidine, a substance found in the human body and almost all plants and animals, can slow down the cellular aging process and influence your overall health.
‘Where we see spermidine work is at a very, very base level to correct the autophagy to get rid of those bad mitochondria so that now we’re not being overwhelmed by reactive oxygen species,’ Dr. Yurth says. ‘We actually will start to recycle the bad parts of the cell and start with a new cell at that point.’”

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SpermidineLIFE is featured in this podcast, a product that is available on the BLI Store, OHP Health.  For 25% off, Go to OHPHealth.com and use the code DAVE25 at checkout. 

Continue reading “Trigger Autophagy Without Fasting – Dr. Elizabeth Yurth Talks Spermidine with Dave Asprey”

Recipe for Injury Rehab & Prevention

Enjoy this healthy recipe which features Collagen, a key ingredient if you’re concerned about inflammation.  Collagen helps in these areas:

  • Support for the health of your joints, tendons and connective tissue
  • Comfort and mobility support
  • Assistance in building muscle
  • Heart and blood vessel health support
  • Overall health with gut and promotion of healthy hair, nails & skin

DISCLAIMER: All information, content, and material of this presentation is for informational purposes only and are not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.

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